Deep TMS was developed by Prof. Abraham Zengen in 2001. It was patented by the American National Institute of Mental Health and the company Brainsway. It was approved by the U.S. Food and Drug Administration in 2003. Although reported to be applicable on children, it is advised to be implemented on people over 16 years of age.

Deep TMS is a drug-free and non-surgical treatment that does not require anesthetics. The patient is awake and conscious during the implementation. The target area of the brain is physically stimulated by sending magnetic pulses under the skull through a mechanism placed onto the skull. Therefore, the neurons functioning over electrical activity become active via magnetic stimulation.


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    What are the disorders treated by Deep TMS?

    In psychiatry, Deep TMS is being implemented at high success rates in the following disorders in many countries around the world:


    • Major Depression
    • Anxiety Disorder


    • Obsessive Compulsive Disorder (OCD)

    Does Deep TMS have side effects?

    No side effects have been spotted excluding the temporary situations such as temporary headaches, temporary ringing in the ears, etc. during the application. It is safe and tolerable. In the case that the ache continues following the first couple of sessions, it is not harmful to take painkillers. Following the application, the patients may continue their daily routines, such as driving cars. It does not cause temporary memory loss, weight gain, xerostomia or sexual problems.

    Why is Deep TMS important in terms of addiction treatment?

    It is extremely significant to regulate the impaired brain parts during the treatment, due to the fact that addiction is a disease that is quite challenging to treat. Today, addiction is known to be a chronic and recurrent brain disorder like schizophrenia, or a chronic disease with a long-term treatment like diabetes. Addiction does not stem from a defective intention, lack of personality or moral weakness. It is caused by the changes in hormones named “neurotransmitters”, such as dopamine, in the areas called “nucleus accumbens” located deep in the brain. Strong treatments like brain stimulation can be effective in reversing such changes.

    In which cases is Deep TMS required?

    It is required for a fast and effective solution, if it is suitable for the patient to take a Deep TMS treatment. Furthermore, it is required in terms of preventing recurrence in treatment-resistant depression, in cases entailing drug-free treatment, and in addiction. In addiction patients, particularly in cases where post-treatment recurrence comes into question, it is required to use the Deep TMS method if the patient seeks the substance that causes addiction despite the known treatments.

    Is Deep TMS risky in terms of health?

    Deep TMS is a low-risk practice just like regular TMS. Both Deep TMS and regular TMS are quite low-risk methods of application as no interventional procedures are applied on the patient, when compared to other methods of brain stimulation. This method does not cause any damage on the brain.


    Deep TMS and Major Depression

    Major depression is a serious brain disorder that complicates the individual’s life. In addition to drugs and psycho-social intervention, TMS is also a method administered particularly for patients who are treatment-resistant, complain about the side effects of drugs, have liver-kidney problems or who are pregnant and puerperal. In the major depression protocol, thanks to the magnetic field applied on the left dorsolateral prefrontal cortex (DLPFC) of the brain, the cortical blood flow, glucose and oxygen consumption, which have slowed down due to depression, go back to their usual speed. This causes an antidepressant effect. The brain areas, where significant changes have been observed following the TMS application, are the left anterior cingulate cortex, left insula, left upper temporal gyrus and right angular gyrus. An increase of volume in these areas and a decrease in the severity of depression have been found to be correlated. In addition to the aforementioned areas, Deep TMS is also capable of reaching the nucleus accumbens and frontal tegmentum area due to the fact that it effects a deeper and wider area. This difference between standard TMS and Deep TMS makes Deep TMS more effective in the treatment of major depression.

    Deep TMS and Obsessive Compulsive Disorder

    Obsessive Compulsive Disorder (OCD) is defined as intensely disturbing thoughts and repetitive behaviors. According to the neurobiological model, OCD is associated with motor areas, cortico-striato-thalamo-cortical pathways, prefrontal cortex and orbitofrontal cortex. Deep TMS aims at the medial prefrontal cortex and anterior cingulate cortex. Emotional and cognitive processes become integrated, while the there is an improvement in the control, attention, planning and short-term memory functions of the patient through the deep stimulation of such areas.

    Deep TMS and Anxiety Disorder



    What is the method of applying the treatment with a Deep TMS device that is available only at limited centers in Turkey and around the world?
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