Deep TMS and Major Depression
Major depression is a serious brain disorder that complicates the individual’s life. In addition to drugs and psycho-social intervention, TMS is also a method administered particularly for patients who are treatment-resistant, complain about the side effects of drugs, have liver-kidney problems or who are pregnant and puerperal. In the major depression protocol, thanks to the magnetic field applied on the left dorsolateral prefrontal cortex (DLPFC) of the brain, the cortical blood flow, glucose and oxygen consumption, which have slowed down due to depression, go back to their usual speed. This causes an antidepressant effect. The brain areas, where significant changes have been observed following the TMS application, are the left anterior cingulate cortex, left insula, left upper temporal gyrus and right angular gyrus. An increase of volume in these areas and a decrease in the severity of depression have been found to be correlated. In addition to the aforementioned areas, Deep TMS is also capable of reaching the nucleus accumbens and frontal tegmentum area due to the fact that it effects a deeper and wider area. This difference between standard TMS and Deep TMS makes Deep TMS more effective in the treatment of major depression.
Deep TMS and Obsessive Compulsive Disorder
Obsessive Compulsive Disorder (OCD) is defined as intensely disturbing thoughts and repetitive behaviors. According to the neurobiological model, OCD is associated with motor areas, cortico-striato-thalamo-cortical pathways, prefrontal cortex and orbitofrontal cortex. Deep TMS aims at the medial prefrontal cortex and anterior cingulate cortex. Emotional and cognitive processes become integrated, while the there is an improvement in the control, attention, planning and short-term memory functions of the patient through the deep stimulation of such areas.
Deep TMS and Anxiety Disorder