In the experimental model test animals are given neuroleptics for a period of several weeks. If the drug is withdrawn a dopamine receptor supersensitivity sets in.<\/p>\n
If in such a situation a dopamine antagonist is introduced, stereotypical behavior appears. This condition is called behavioral sensitivity.<\/p>\n
The reason for the sensitivity is receptor proliferation (increased production) due to chronic receptor blockage.<\/p>\n
The following instruments are used in the research:<\/p>\n
\u2013 SCH23390 (Selective D1 receptor antagonist)
\n\u2013 SKF38393 (Selective D1 receptor agonist)
\n\u2013 Raclopride (Selective D2 receptor antagonist)
\n\u2013 LY171555 (Selective D2 receptor agonist)<\/p>\n
Immobility associated with antidopaminergic\/antipsychotic drugs.
\nBoth D1 and D2 antagonists can cause this. Using them together creates a synergic effect.<\/p>\n
The measuring is undertaken on the 1st and 21st day of drug use. It is assessed how many minutes the animal whose front legs are placed on a vertical bar, can hold this position.<\/p>\n
\u2013 Animals that have continuously been given neuroleptics are injected with apomorphine (a dopamine agonist).
\n\u2013 0=normal behavior
\n\u2013 1=constant loco-motor movement; rearing (movement towards the tail), sniffing, licking absent.
\n\u2013 2=medium loco-motor movement. Continuous sniffing.
\n\u2013 3=intermittent loco-motor activity
\n\u2013 4=constant licking, gnawing biting, infrequent loco-motor activity.<\/p>\n
\u2013 Receptor ligands bound with Iodine 125 are used (SCH 23982 for D1, Sulpiride for D2).
\n\u2013 Applied to 20 micrometer brain sections.
\n\u2013 After a certain period of incubation it is brought into contact with the film.
\n\u2013 Finally the striatal area on the film is measured with an optic dansitometer.<\/p>\n
\u2013 Created by the effect of antagonist D1 and D2.<\/p>\n
\u2013 Negative PET findings
\n\u2013 Why relapse?
\n\u2013 Why resistance to treatment?<\/p>\n","protected":false},"excerpt":{"rendered":"
In the experimental model test animals are given neuroleptics for a period of several weeks. If the drug is withdrawn a dopamine receptor supersensitivity sets in. If in such a situation a dopamine antagonist is introduced, stereotypical behavior appears. This condition is called behavioral sensitivity. The reason for the sensitivity is receptor proliferation (increased production) […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[501],"tags":[],"class_list":["post-866","post","type-post","status-publish","format-standard","hentry","category-articles"],"acf":[],"yoast_head":"\n